We also observed a significant difference in the performance of a multiethnic genetic risk score (GRS) across population groups (p heterogeneity = 3.85 × 10 −20). We identified a multiethnic risk variant in the BACE2 gene (rs13052926, RAF = 14.1%, OR = 1.08, p = 5.75 × 10 −9), which also replicated in independent studies (p = 3.45 × 10 −4). In individuals of African ancestry, we discovered a risk variant in the TGFB1 gene (rs11466334, risk allele frequency (RAF) = 6.8%, odds ratio = 1.27, p = 2.06 × 10 −8), which replicated in independent studies of African ancestry (p = 6.26 × 10 −23). We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, and European population groups in the Population Architecture Genomics and Epidemiology (PAGE) and Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortia. Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. North, 2 Steven Buyske, 39 Charles Kooperberg, 37 Ruth J.F. Phillips, 34, 35 Ulrike Peters, 36 Chris Carlson, 37 Lynne R.

Pankow, 29 Martha Daviglus, 30 Qibin Qi, 31 Eric A. Nadkarni, 8 Mariaelisa Graff, 2 Ran Tao, 28 James S. Bielak, 21 Salman Tajuddin, 22 Aude Nicolas, 23 Guanjie Chen, 24 Laura Raffield, 25 Xiuqing Guo, 26 Wei-Min Chen, 27 Girish N.

Jensen, 16 Meng Sun, 17 Yoonjung Yoonie Joo, 18 Ping An, 19 Lisa R. Mercader, 10 Teresa Tusie-Luna, 11 Clicerio González-Villalpando, 12 Lorena Orozco, 13 Cassandra N. Below, 4 Lauren Petty, 4 Stephanie Bien, 5 Xueling Sim, 6 Wei Wang, 7 Pierre Fontanillas, 7 Yesha Patel, 1 The 23andMe Research Team, DIAMANTE Hispanic/Latino Consortium, MEta-analysis of type 2 DIabetes in African Americans Consortium, Michael Preuss, 8 Claudia Schurmann, 8 Zhaohui Du, 1 Yingchang Lu, 3 Suhn K. Darst, 1, 41 Heather Highland, 2 Xin Sheng, 1 Maggie C.Y.

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